| Year | Winner | Title of dissertation |
| 2022 | dr. Alexander Bakker | Discovery of Antibiotics and Their Targets in Multidrug-Resistant Bacteria |
| 2020 | dr. Natalia Ortiz Zacarías | The road to insurmountability – novel avenues to better target CC Chemokine Receptors |
| 2018 | dr. Marc Baggelaar | Activity-based protein profiling of diacylglycerol lipases |
| 2016 | dr. Marcel Scheepstra | Molecular modulation of nuclear receptor conformational states |
| 2014 | dr Dong Guo | Drug-Target Residence Time. A case for the adenosine A1 and A2a receptors |
| 2012 | dr.ir. Harald Albers | Development of ATX and DUSP inhibitors; Inhibiting phosphate ester hydrolysis in biology |
| 2010 | dr. Rogier Smits | Design and Synthesis of New Histamine H4 Receptor Ligands |
| 2008 | dr. Tom Wennekes | Lipophilic iminosugars: synthesis and evaluation as inhibitors of glucosylceramide metabolism |
| 2006 | dr. Lisa Chang | Novel ligands for the human adenosine A1 receptor |
| 2004 | dr. Martijn Rooseboom | Novel Organoselenium Prodrugs - Mechanisms of Bioactivation, Kidney Selectivity and Chemoprotective Properties of Selenicysteine Se-Conjugates |
| 2002 | dr. Vincent de Groot | New approaches in selective chemotherapy with tumor-activated prodrugs |
| 2000 | dr. M. van der Mey | Novel Phosphodiesterase inhibitors. Synthesis, structure-activity relationships and molecular modeling of selective PDE-4 and dual PDE-3/4 inhibitors |
| 1998 | dr. M. Zwaagstra | Molecular recognition of the Leucotriene cys LT1-receptor |
| 1996 | dr. R.C. Vollinga | New ligands of the histamine H3-receptor. Synthesis, structure activity relationships and molecular pharmacology |
| 1994 | dr. W.H.A. Kuijpers | Synthesis of modified oligodeoxynucleotides for application in radioimmunotherapy |
| 1992 | dr. G.M.T. van Wijk | Phospholipid conjugates of antiviral agents. Synthesis, metabolism and biological activity |
| 1990 | dr. G.S. Baldew | Chemoprotection against cisplatin nephrotoxicity: a molecular approach with selenium compounds |
| 1988 | dr. L.A.G.M. van de Broek | Synthetic endeavours involving sparsomycin: the development of an antitumor antibiotic |
