Stabilization of Protein-Protein Interactions
Stabilization of Protein-Protein Interactions; from chemical biology concept to medicinal chemistry application
Since the MedCHEMBio2021 conference had to be cancelled due to COVID-19, a webinar is organised to ease the suffering.
Luc Brunsveld: "Our group combines organic synthesis, protein chemistry, structural biology, and supramolecular chemistry to perform chemical biology studies on protein-protein interactions (PPIs) with the aim to enable innovative medicinal chemistry for ‘molecular glues’ for PPIs. In this presentation I aim to show that a “supramolecular” point of view to protein-protein interactions (PPIs) helps to unravel the underlying, more complex, interaction mechanisms. This ‘systems approach’ to PPIs allows to recognize and apply concepts such as multivalency and cooperativity within the context of drug discovery. Using nuclear receptors and 14-3-3 proteins as examples the webinar aims to provide answers to questions such as:
- How can chemical biology studies steer medicinal chemistry for PPIs?
- What are the key physical-chemical characteristics of molecules that stabilize PPIs?
- How can we find chemical starting point for PPI stabilization?"
More information can be found on the website.